Nucleotide salvage

Across TCGA cell cohorts, RNA activity of the Nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS16, MCM7, and KATNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide salvage activity versus RGS16 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RGS16 →	+2.166	+0.190	.003	.009	3	6
BREAST	MCM7 →	+0.754	+0.900	<.001	.003	3	6
BREAST	KATNB1 →	+0.800	+0.658	<.001	.004	3	6
UPPER_AERODIGESTIVE_TRACT	WDR33 →	+0.672	+1.471	.003	.005	3	5
BLOOD_Myeloma	EID2B →	+1.103	+0.273	.003	.001	3	5
STOMACH	PPAN →	+0.705	+0.947	.007	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043173 vs RGS16 — BLOOD_Lymphoma

Explore this scatter interactively →