Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL4R, ARRDC1, and RNF149, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL4R grouped by Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL4R →	+1.544	+0.285	<.001	.006	3	6
UPPER_AERODIGESTIVE_TRACT	ARRDC1 →	+1.610	+0.313	<.001	.004	3	6
LARGE_INTESTINE	RNF149 →	+0.752	+0.339	.005	.001	3	6
PANCREAS	NECTIN4 →	+2.142	+0.237	<.001	<.001	3	5
PANCREAS	FXYD3 →	+3.946	+0.191	.001	.001	3	5
BLOOD_Myeloma	RFXANK →	-0.897	-0.485	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL4R by Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway activity — URINARY_TRACT

Explore this box plot interactively →