Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and LGG, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.920	0.810	<.001	59	view →
ACC	OS	Median	All	0.298	0.757	<.001	45	view →
KIRP	DFS	Median	All	0.782	0.914	.002	41	view →
LGG	OS	Median	All	0.543	0.374	<.001	39	view →
SCLC	DFS	Tertile	II,III,IV	0.624	0.215	.005	28	view →
HNSC	DFS	Median	IV	0.391	0.261	.012	23	view →
BRCA	DFS	Tertile	III,IV	0.847	0.690	.005	22	view →
LUSC	OS	Tertile	All	0.830	0.703	.007	20	view →
PCPG	OS	Median	All	0.728	1.000	.014	15	view →
KICH	OS	Median	II,III,IV	0.876	1.000	.016	14	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →
OV	OS	Tertile	IV	0.921	0.616	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0043162–KIRC (OS)

Open the KIRC breakdown →