Amyloid precursor protein metabolic process

Across TCGA patient cohorts, RNA activity of the Amyloid precursor protein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC7A, PIMREG, and MNDA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid precursor protein metabolic process activity versus CLEC7A in BRCA (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC7A →	+0.756	+0.210	<.001	<.001	3	5
UCEC	PIMREG →	-0.675	-0.178	.002	.006	3	4
BRCA	MNDA →	+0.778	+0.249	<.001	<.001	3	4
BRCA	SDCBP →	+0.831	+0.220	<.001	<.001	3	4
BRCA	LY96 →	+0.496	+0.159	.006	.001	3	4
BRCA	HDX →	+0.548	+0.134	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042982 vs CLEC7A — BRCA

Explore this scatter interactively →