Amyloid precursor protein metabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid precursor protein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMC1, TRIM73, and MKKS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMC1 grouped by Amyloid precursor protein metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FMC1 →	+1.296	+1.210	<.001	<.001	3	5
OVARY	TRIM73 →	+1.157	+1.193	.007	<.001	3	5
BREAST	MKKS →	+0.693	+0.950	.006	<.001	3	4
LUNG_SCLC	CCNI →	+0.784	+1.516	<.001	<.001	3	4
STOMACH	PDS5A →	+0.618	+1.023	.002	<.001	3	4
STOMACH	KMT2E →	+0.839	+1.119	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMC1 by Amyloid precursor protein metabolic process activity — BREAST

Explore this box plot interactively →