Amyloid precursor protein metabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid precursor protein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM9, OPTN, and PML, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid precursor protein metabolic process activity versus ADAM9 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM9 →	+0.804	+0.386	.002	.006	3	6
BLOOD_Lymphoma	OPTN →	+3.124	+1.151	.001	.001	2	6
LUNG_NSCLC_LUAD	PML →	+0.984	+0.212	.001	.005	3	5
BONE	APOL1 →	+3.495	+0.297	<.001	<.001	2	5
LARGE_INTESTINE	TNFRSF21 →	+1.022	+0.448	<.001	.001	3	4
LARGE_INTESTINE	ITGB1 →	+0.724	+0.419	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042982 vs ADAM9 — LARGE_INTESTINE

Explore this scatter interactively →