Negative regulation of circadian rhythm

Across TCGA patient cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PURA_S256, GPATCH4, and GSTK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of circadian rhythm activity versus PURA_S256 in CCRCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PURA_S256 →	+0.457	+0.076	.001	.002	3	5
BRCA	GPATCH4 →	-0.364	-0.043	.001	.009	3	5
BRCA	GSTK1 →	-0.222	-0.046	.002	.003	3	5
HNSC	YLPM1 →	+0.174	+0.063	.002	<.001	2	5
BRCA	CCDC88C →	+0.283	+0.044	.004	.008	3	4
BRCA	OSBP_S240 →	-0.844	-0.093	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042754 vs PURA_S256 — CCRCC

Explore this scatter interactively →