Negative regulation of circadian rhythm

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of circadian rhythm pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, UVM, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.896	0.987	.001	51	view →
UVM	DFS	Median	II,III,IV	0.778	0.474	.004	51	view →
BRCA	OS	Quartile	III,IV	0.985	0.838	.003	40	view →
KIRC	DFS	Tertile	All	0.868	0.698	.005	17	view →
BLCA	OS	Median	III,IV	0.515	0.630	.014	15	view →
THCA	DFS	Quartile	All	0.970	0.540	<.001	15	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	12	view →
LIHC	OS	Quartile	III,IV	0.890	0.477	.001	12	view →
LUAD	OS	Quartile	All	0.248	0.609	.011	9	view →
DLBC	OS	Median	All	0.765	0.961	.031	8	view →
GBM	DFS	Tertile	All	0.183	0.355	.018	6	view →
PAAD	OS	Tertile	II,III,IV	0.453	0.655	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0042754–KIRP (OS)

Open the KIRP breakdown →