Negative regulation of circadian rhythm

Across TCGA patient cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2SP2, VPS33B, and GINS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of circadian rhythm activity versus UBE2SP2 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBE2SP2 →	+0.446	+0.628	.009	.004	3	4
OV	VPS33B →	+0.344	+0.351	.001	.002	3	3
COAD	GINS2 →	+0.463	+0.549	.003	.001	3	3
COAD	MXRA7 →	-0.603	-0.475	.001	.004	3	3
GBM	WDR92 →	+0.426	+0.731	<.001	.001	3	3
GBM	CEP131 →	+0.329	+0.439	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042754 vs UBE2SP2 — GBM

Explore this scatter interactively →