Negative regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC49A4, TMEM9B, and ANKRD20A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC49A4 grouped by Negative regulation of circadian rhythm-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC49A4 →	+0.673	+0.155	.002	.001	3	3
BREAST	TMEM9B →	+0.966	+0.183	<.001	.002	3	3
SKIN	ANKRD20A1 →	+0.968	+0.223	<.001	<.001	3	3
LIVER	USP18 →	-1.585	-0.303	.008	.001	3	3
SOFT_TISSUE	ROGDI →	-0.947	-0.240	.007	.006	3	3
UPPER_AERODIGESTIVE_TRACT	DBP →	-1.626	-0.253	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC49A4 by Negative regulation of circadian rhythm activity — BREAST

Explore this box plot interactively →