Negative regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNIP4, RBL1, and ATP13A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNIP4 grouped by Negative regulation of circadian rhythm-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KCNIP4 →	+0.236	+0.108	.002	.006	3	2
OVARY	RBL1 →	-0.137	-0.083	.001	.005	3	2
LUNG_NSCLC_LUAD	ATP13A1 →	-0.197	-0.182	.009	<.001	3	2
LUNG_NSCLC_LUAD	CHST10 →	+0.261	+0.157	.003	.001	3	2
LUNG_NSCLC_LUAD	C19orf12 →	-0.295	-0.180	.004	.001	3	2
LUNG_NSCLC_LUAD	TRIM48 →	-0.296	-0.166	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNIP4 by Negative regulation of circadian rhythm activity — OVARY

Explore this box plot interactively →