Negative regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Negative regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGL2, PPFIBP2, and CSF1R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of circadian rhythm activity versus RGL2 in LUNG_SCLC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RGL2 →	-0.752	-0.204	.004	<.001	3	3
BLOOD_Leukemia	PPFIBP2 →	-1.762	-0.143	.002	<.001	3	3
BLOOD_Leukemia	CSF1R →	-2.768	-0.122	.007	<.001	3	3
LUNG_NSCLC_LUAD	BTN2A2 →	-1.975	-0.180	.003	.001	3	3
LARGE_INTESTINE	BAG5 →	-0.644	-0.073	.007	.008	3	3
PANCREAS	DEPP1 →	-2.070	-0.156	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042754 vs RGL2 — LUNG_SCLC

Explore this scatter interactively →