Positive regulation of circadian rhythm

Across TCGA patient cohorts, RNA activity of the Positive regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX39B, SPP1, and APOLD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of circadian rhythm activity versus DDX39B in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX39B →	+0.551	+0.140	.004	.002	3	5
LSCC	SPP1 →	-1.195	-0.157	<.001	<.001	3	4
LSCC	APOLD1 →	+0.500	+0.156	.005	.004	3	4
GBM	RHOA-IT1 →	+0.351	+0.159	<.001	.005	2	5
UCEC	SRSF4 →	+0.362	+0.151	<.001	<.001	3	4
GBM	CAHM →	-0.973	-0.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042753 vs DDX39B — UCEC

Explore this scatter interactively →