Q-omics provides the consensus-scored CAHM profile across patient tissues and cancer cell-line models. CAHM expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CAHM is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, CAHM RNA expression shows 16,538 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, KICH, and UVM as cancer lineages where CAHM shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CAHM — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CAHM survival associations across molecular data types. CAHM RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CAHM RNA expression–survival associations across cancer types. High CAHM expression shows unfavorable associations in KIRC, ACC, UCEC and LIHC, but favorable associations in UCS and PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for CAHM RNA expression.
This table summarizes CAHM tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for CAHM. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CAHM shows lower tumor expression in KICH, LUAD, BRCA and KIRC and higher tumor expression in LIHC and CHOL. The KICH box plot shows higher CAHM RNA expression in normal versus tumor tissue (log2 FC = −1.377, t-test p < 0.001).
This table shows molecular features associated with CAHM in patient tissues and cancer cell lines. In patient samples, CAHM shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
