CAHM

Across TCGA pan-cancer cohorts, CAHM RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CAHM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CAHM RNA is repressed in tumor relative to normal tissue. In most cancer types CAHM is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LIHC, and LUAD are the cancer types where CAHM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAHM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.377	<.001	8	view →
LIHC	Female	All	+0.485	<.001	8	view →
LUAD	Female	II,III,IV	−0.486	<.001	7	view →
BRCA	All	III,IV	−0.795	<.001	6	view →
KIRC	Male	II,III,IV	−0.458	<.001	5	view →
CHOL	All	All	+1.147	<.001	4	view →
THCA	All	All	−0.310	.006	3	view →
READ	Female	All	−0.640	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CAHM–KICH

Open the KICH breakdown →