Positive regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Positive regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C11, CEMIP2, and ATXN7L3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of circadian rhythm activity versus H3C11 in SKIN (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H3C11 →	-0.197	-0.268	.004	.009	3	2
BLOOD_Lymphoma	CEMIP2 →	-3.316	-0.390	.007	.003	3	2
LUNG_NSCLC_LUAD	ATXN7L3 →	+0.615	+0.200	.008	.007	3	1
LUNG_NSCLC_LUAD	MACROH2A2 →	+4.299	+0.200	<.001	.007	3	1
SKIN	RAB36 →	-2.189	-0.268	.005	.009	3	1
SKIN	ZCCHC7 →	-1.855	-0.268	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042753 vs H3C11 — SKIN

Explore this scatter interactively →