Regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNF4G, SMC4, and SIN3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of circadian rhythm activity versus HNF4G in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HNF4G →	-2.476	-0.213	<.001	<.001	3	6
BLOOD_Leukemia	SMC4 →	+0.722	+0.146	.008	<.001	3	6
LUNG_SCLC	SIN3A →	+0.618	+0.143	<.001	<.001	3	6
URINARY_TRACT	OLFML2A →	+2.793	+0.219	<.001	.001	3	6
BREAST	DBF4B →	+1.021	+0.232	.005	<.001	3	5
LARGE_INTESTINE	TCTN2 →	+0.903	+0.131	.002	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042752 vs HNF4G — STOMACH

Explore this scatter interactively →