Embryonic digit morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic digit morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT140, CROCC, and WARS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digit morphogenesis activity versus IFT140 in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFT140 →	+0.810	+0.037	<.001	<.001	3	8
UCEC	CROCC →	+0.559	+0.059	<.001	<.001	3	8
HNSC	WARS1 →	-0.626	-0.043	<.001	<.001	3	7
BRCA	WDR19 →	+0.264	+0.025	<.001	<.001	3	7
UCEC	WDR35 →	+0.355	+0.056	.001	.002	3	7
BRCA	FAM172A →	+0.291	+0.030	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042733 vs IFT140 — COAD

Explore this scatter interactively →