Embryonic digit morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic digit morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1B, BIN1, and SSTR3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digit morphogenesis activity versus ACVR1B in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACVR1B →	+0.584	+0.513	<.001	.001	3	6
BRCA	BIN1 →	-0.997	-0.755	<.001	<.001	3	5
GBM	SSTR3 →	-0.596	-0.598	<.001	<.001	3	5
LSCC	TOMM20 →	+0.458	+0.490	.001	.008	3	5
BRCA	TADA1 →	+0.406	+0.517	.003	.001	3	5
BRCA	TRPS1 →	+1.118	+0.844	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042733 vs ACVR1B — BRCA

Explore this scatter interactively →