Mechanoreceptor differentiation

Across TCGA patient cohorts, RNA activity of the Mechanoreceptor differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZMYM2, PHC1, and ZC3HAV1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mechanoreceptor differentiation activity versus ZMYM2 in HNSC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZMYM2 →	+0.283	+0.037	<.001	<.001	3	6
LSCC	PHC1 →	+0.476	+0.028	.001	.001	3	6
CCRCC	ZC3HAV1 →	-0.122	-0.026	<.001	<.001	3	5
BRCA	CROCC →	+0.245	+0.023	.001	<.001	3	5
LSCC	IGFBP2 →	+1.039	+0.035	<.001	<.001	3	5
LSCC	MICAL1 →	-0.287	-0.025	.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042490 vs ZMYM2 — HNSC

Explore this scatter interactively →