Mechanoreceptor differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Mechanoreceptor differentiation pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 67 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Mechanoreceptor differentiation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and COAD, show the opposite pattern, with higher activity associated with better survival.

BLCA, COAD, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.780	0.662	.002	40	view →
COAD	OS	Tertile	II,III,IV	0.937	0.729	.001	33	view →
MESO	DFS	Quartile	II,III,IV	0.251	0.513	.010	33	view →
ACC	DFS	Quartile	II,III,IV	0.126	0.804	<.001	29	view →
LIHC	DFS	Median	All	0.482	0.616	.004	26	view →
LUSC	OS	Quartile	All	0.766	0.589	.003	24	view →
BRCA	OS	Median	III,IV	0.956	0.850	.001	22	view →
GBM	DFS	Tertile	All	0.331	0.197	.005	21	view →
READ	DFS	Tertile	All	0.852	0.478	.003	20	view →
LGG	OS	Tertile	All	0.841	0.717	.001	15	view →
KIRC	OS	Tertile	All	0.512	0.693	.007	13	view →
HNSC	DFS	Tertile	III,IV	0.665	0.511	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0042490–BLCA (OS)

Open the BLCA breakdown →