Mechanoreceptor differentiation

Across TCGA cell cohorts, RNA activity of the Mechanoreceptor differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT52, CCSER2, and CTIF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT52 grouped by Mechanoreceptor differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFT52 →	-0.709	-0.234	.001	.003	3	3
LUNG_NSCLC_LUAD	CCSER2 →	-0.623	-0.209	.007	.001	3	3
SKIN	CTIF →	-0.734	-0.194	.005	.009	3	3
LIVER	TMED7 →	-0.564	-0.251	.007	.004	3	3
SKIN	ZNF41 →	-0.562	-0.255	.007	.003	3	3
SKIN	UBXN6 →	-0.473	-0.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT52 by Mechanoreceptor differentiation activity — SKIN

Explore this box plot interactively →