Water-soluble vitamin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPM4, RFC2, and RFC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Water-soluble vitamin biosynthetic process activity versus TPM4 in BRCA (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPM4 →	-0.502	-0.042	<.001	<.001	3	5
LSCC	RFC2 →	+0.266	+0.039	<.001	<.001	3	5
LSCC	RFC5 →	+0.265	+0.036	<.001	<.001	3	5
CCRCC	VCL_S290 →	-0.350	-0.043	.008	.001	3	5
BRCA	OLFML3 →	-0.668	-0.034	<.001	.001	3	5
BRCA	CEBPZ →	+0.321	+0.040	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042364 vs TPM4 — BRCA

Explore this scatter interactively →