Water-soluble vitamin biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Water-soluble vitamin biosynthetic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and LUSC, show the opposite pattern, with higher activity associated with better survival.

PAAD, LUSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.613	0.297	<.001	72	view →
LUSC	DFS	Tertile	All	0.496	0.328	.004	54	view →
KIRC	DFS	Tertile	All	0.713	0.903	<.001	47	view →
UVM	DFS	Tertile	III,IV	0.306	0.761	.002	40	view →
LGG	DFS	Tertile	All	0.791	0.911	<.001	21	view →
SKCM	DFS	Tertile	All	0.373	0.217	.006	14	view →
SARC	DFS	Quartile	All	0.479	0.704	.006	11	view →
PRAD	DFS	Median	All	0.909	0.953	.016	10	view →
CHOL	OS	Median	II,III,IV	0.080	0.740	.026	9	view →
STAD	DFS	Quartile	II,III,IV	0.233	0.484	.026	7	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →
UCEC	OS	Quartile	All	0.915	0.952	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0042364–PAAD (OS)

Open the PAAD breakdown →