Water-soluble vitamin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPK1, TESPA1, and GPR65, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Water-soluble vitamin biosynthetic process activity versus TPK1 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TPK1 →	+0.464	+0.154	.003	.006	3	6
LSCC	TESPA1 →	+0.521	+0.270	<.001	<.001	3	5
LSCC	GPR65 →	+0.457	+0.268	<.001	<.001	3	5
LSCC	FGD2 →	+0.541	+0.233	<.001	<.001	3	5
LSCC	SNX20 →	+0.471	+0.207	<.001	<.001	3	5
LSCC	INPP5D →	+0.596	+0.201	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042364 vs TPK1 — LUAD

Explore this scatter interactively →