Water-soluble vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL1, EID3, and GBGT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FHL1 grouped by Water-soluble vitamin biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FHL1 →	+2.994	+1.371	<.001	<.001	3	5
KIDNEY	EID3 →	+1.158	+1.139	<.001	.003	3	4
BREAST	GBGT1 →	+0.836	+0.662	.001	.009	3	4
CNS	PRSS16 →	+0.676	+0.977	.006	<.001	3	3
SKIN	TNFRSF10B →	-0.763	-0.800	<.001	.002	3	3
CNS	NFKBID →	-0.649	-0.952	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FHL1 by Water-soluble vitamin biosynthetic process activity — BREAST

Explore this box plot interactively →