Water-soluble vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IHH, FASTK, and MAX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IHH grouped by Water-soluble vitamin biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IHH →	+0.206	+0.114	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	FASTK →	-0.302	-0.116	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MAX →	+0.410	+0.093	<.001	.004	3	4
LUNG_NSCLC_LUSC	PINK1 →	+0.258	+0.143	.003	.002	3	4
OVARY	EHBP1 →	+0.181	+0.124	<.001	.001	3	4
SOFT_TISSUE	ACER3 →	-0.211	-0.097	.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IHH by Water-soluble vitamin biosynthetic process activity — BREAST

Explore this box plot interactively →