Water-soluble vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Water-soluble vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSAT1, RNPEPL1, and GARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Water-soluble vitamin biosynthetic process activity versus PSAT1 in BLOOD_Leukemia (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSAT1 →	+3.431	+1.355	<.001	<.001	3	6
LUNG_NSCLC_LUSC	RNPEPL1 →	+1.586	+2.303	.006	<.001	3	5
BLOOD_Leukemia	GARS1 →	+0.767	+0.794	<.001	.002	3	5
BLOOD_Lymphoma	TOM1L1 →	+1.505	+0.871	.009	.008	2	6
BLOOD_Leukemia	ANK1 →	+1.728	+0.789	.008	<.001	3	4
STOMACH	PPIL3 →	+0.829	+1.091	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042364 vs PSAT1 — BLOOD_Leukemia

Explore this scatter interactively →