Fat-soluble vitamin catabolic process

Across TCGA patient cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYP4F11, PPL, and HDGFL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat-soluble vitamin catabolic process activity versus CYP4F11 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYP4F11 →	+1.238	+0.229	<.001	.008	2	7
UCEC	PPL →	+0.694	+0.750	<.001	<.001	3	5
CCRCC	HDGFL3 →	-0.374	-0.667	<.001	<.001	3	5
COAD	SP4 →	-0.520	-0.088	.006	.008	3	4
CCRCC	HTATIP2 →	+0.459	+0.584	<.001	<.001	3	4
LSCC	PHLDB1_S404 →	-0.327	-0.178	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042363 vs CYP4F11 — LSCC

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