Fat-soluble vitamin catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and LIHC, show the opposite pattern, with lower activity in tumor tissue.

KIRC, LIHC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Male	All	−0.122	<.001	11	view →
LIHC	Female	II,III,IV	−0.231	<.001	9	view →
LUSC	Male	III,IV	+0.372	<.001	8	view →
LUAD	Female	II,III,IV	+0.181	<.001	8	view →
HNSC	Male	All	+0.078	<.001	8	view →
CHOL	All	All	−0.400	<.001	5	view →
THCA	Male	III,IV	−0.149	<.001	5	view →
BRCA	All	All	−0.062	.025	4	view →
KIRP	Male	III,IV	−0.098	.042	2	view →
PRAD	All	All	−0.047	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0042363–KIRC

Open the KIRC breakdown →