Fat-soluble vitamin catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Fat-soluble vitamin catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and LIHC, show the opposite pattern, with higher activity associated with better survival.

CESC, LIHC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	IV	0.544	0.090	.001	94	view →
LIHC	OS	Tertile	All	0.782	0.602	<.001	57	view →
HNSC	OS	Tertile	IV	0.252	0.615	.001	47	view →
KIRP	DFS	Quartile	II,III,IV	0.694	0.322	.008	37	view →
STAD	DFS	Quartile	All	0.690	0.495	.004	36	view →
LGG	DFS	Median	All	0.776	0.874	<.001	35	view →
UVM	DFS	Tertile	All	0.857	0.413	.010	33	view →
LUAD	DFS	Median	All	0.682	0.850	<.001	30	view →
CHOL	DFS	Median	II,III,IV	0.138	0.569	.001	27	view →
DLBC	DFS	Quartile	III,IV	1.000	0.162	.006	25	view →
LUSC	DFS	Tertile	III,IV	0.803	0.532	.002	24	view →
READ	DFS	Median	II,III,IV	0.360	0.847	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0042363–CESC (OS)

Open the CESC breakdown →