Fat-soluble vitamin catabolic process

Across TCGA patient cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC17, PSMD14, and CLIP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat-soluble vitamin catabolic process activity versus DNAJC17 in CCRCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DNAJC17 →	-0.233	-0.529	<.001	.002	3	2
CCRCC	PSMD14 →	+0.263	+0.481	.009	.006	3	2
LSCC	CLIP4 →	+1.163	+0.903	.001	<.001	3	2
CCRCC	OARD1 →	-0.309	-0.670	.005	.009	3	2
CCRCC	SNRPN →	-0.392	-0.704	<.001	.002	3	2
LSCC	MAP1B →	+2.250	+1.204	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042363 vs DNAJC17 — CCRCC

Explore this scatter interactively →