Fat-soluble vitamin catabolic process

Across TCGA cell cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYM1, MST1, and PHLDA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYM1 grouped by Fat-soluble vitamin catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PYM1 →	-0.668	-0.736	.001	.005	3	4
BREAST	MST1 →	-0.681	-0.557	.008	.008	3	4
BREAST	PHLDA3 →	-1.803	-0.783	<.001	.001	3	3
OVARY	RAB31 →	+1.386	+0.679	<.001	.001	3	3
OVARY	SLC9A7 →	+1.182	+0.841	.006	.005	2	4
UPPER_AERODIGESTIVE_TRACT	TNFRSF17 →	-0.084	-0.219	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYM1 by Fat-soluble vitamin catabolic process activity — BREAST

Explore this box plot interactively →