Fat-soluble vitamin catabolic process

Across TCGA cell cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is significantly associated with the total protein of multiple features, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PKC-a, S6_pS240_S244, and PKC-a_pS657, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat-soluble vitamin catabolic process activity versus PKC-a in LUNG_NSCLC_LUAD (Pearson r = 0.91).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PKC-a →	+0.948	+0.295	.033	.015	3	1
LUNG_NSCLC_LUAD	S6_pS240_S244 →	+0.655	+0.324	.026	.041	2	1
LUNG_NSCLC_LUAD	PKC-a_pS657 →	+1.267	+0.295	.033	.015	1	1
LUNG_NSCLC_LUAD	SF2 →	+0.354	+0.295	.010	.015	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest associations by consensus.

GO:0042363 vs PKC-a — LUNG_NSCLC_LUAD

Explore this scatter interactively →