Fat-soluble vitamin catabolic process

Across TCGA cell cohorts, RNA activity of the Fat-soluble vitamin catabolic process pathway is significantly associated with the drug response of multiple features, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are MK-8776, KIN001-244, and KIN001-266, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MK-8776 grouped by Fat-soluble vitamin catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MK-8776 →	-0.769	-0.401	.033	.016	3	1
LUNG_NSCLC_LUAD	KIN001-244 →	-0.715	-0.374	.046	.018	3	1
LUNG_NSCLC_LUAD	KIN001-266 →	-0.650	-0.374	.002	.018	3	1
LUNG_NSCLC_LUAD	PIK-93 →	-0.744	-0.374	.001	.018	3	1
LUNG_NSCLC_LUAD	YM201636 →	-0.719	-0.374	.005	.018	3	1
LUNG_NSCLC_LUAD	Rucaparib →	-0.264	-0.374	.008	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MK-8776 by Fat-soluble vitamin catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →