Fat-soluble vitamin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fat-soluble vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLOC1S2, HSPE1P10, and CYP27A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat-soluble vitamin biosynthetic process activity versus BLOC1S2 in GBM (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BLOC1S2 →	+0.378	+0.219	.001	.002	3	3
PDAC	HSPE1P10 →	-0.080	-0.578	.002	.009	3	3
OV	CYP27A1 →	+0.909	+0.146	<.001	<.001	3	3
CCRCC	RPS6KL1 →	-0.287	-0.422	.006	.005	3	3
GBM	PLTP →	+0.707	+0.203	.003	.002	3	2
GBM	TSPAN12 →	-0.951	-0.216	.008	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042362 vs BLOC1S2 — GBM

Explore this scatter interactively →