Cellular ketone metabolic process

Across TCGA patient cohorts, RNA activity of the Cellular ketone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN7-DT, INE1, and CALM2P2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular ketone metabolic process activity versus SEPTIN7-DT in GBM (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN7-DT →	+0.618	+0.013	<.001	<.001	3	28
KIRC	INE1 →	+0.708	+0.023	<.001	<.001	3	27
KIRC	CALM2P2 →	+0.808	+0.024	<.001	<.001	3	27
UVM	RHOQ-AS1 →	+0.492	+0.016	<.001	<.001	3	27
UVM	CARF →	+0.722	+0.016	<.001	<.001	3	26
READ	PRDX3P1 →	+0.470	+0.013	<.001	.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042180 vs SEPTIN7-DT — GBM

Explore this scatter interactively →