Cellular ketone metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Cellular ketone metabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 226 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cellular ketone metabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PRAD and KIRP, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.478	0.853	.007	66	view →
LGG	OS	Tertile	All	0.293	0.486	<.001	28	view →
UCEC	OS	Tertile	All	0.424	0.752	.003	26	view →
LAML	DFS	Median	All	0.191	0.478	.013	24	view →
GBM	DFS	Tertile	All	0.140	0.339	.010	21	view →
CHOL	OS	Tertile	II,III,IV	0.120	0.869	<.001	21	view →
STAD	OS	Quartile	II,III,IV	0.220	0.563	.003	19	view →
THCA	OS	Tertile	All	0.944	0.991	.005	18	view →
LUAD	DFS	Median	IV	0.666	0.978	.015	18	view →
THYM	OS	Quartile	All	0.907	1.000	.001	13	view →
MESO	OS	Quartile	II,III,IV	0.259	0.509	.031	13	view →
PRAD	DFS	Tertile	All	0.900	0.776	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0042180–UVM (OS)

Open the UVM breakdown →