Cellular ketone metabolic process

Across TCGA patient cohorts, RNA activity of the Cellular ketone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S1132, AKR1C3, and CES1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular ketone metabolic process activity versus SRRM2_S1132 in OV (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRRM2_S1132 →	-0.729	-0.017	<.001	.006	3	7
LSCC	AKR1C3 →	+1.604	+0.027	<.001	<.001	3	7
LSCC	CES1 →	+1.177	+0.024	<.001	<.001	3	6
LUAD	AKR1C2 →	+1.851	+0.030	<.001	<.001	3	6
GBM	RBM25 →	-0.237	-0.021	<.001	<.001	3	6
LSCC	UCHL1 →	+1.178	+0.025	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042180 vs SRRM2_S1132 — OV

Explore this scatter interactively →