Cellular ketone metabolic process

Across TCGA cell cohorts, RNA activity of the Cellular ketone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1A1, CBR1, and UGDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular ketone metabolic process activity versus AKR1A1 in LUNG_SCLC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AKR1A1 →	+1.075	+0.302	<.001	.003	3	6
OVARY	CBR1 →	+1.154	+0.374	.002	<.001	3	6
STOMACH	UGDH →	+2.111	+0.577	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	VDAC1 →	+1.122	+0.382	.005	.001	3	6
SKIN	KRT18 →	-1.990	-0.324	.002	.001	3	5
STOMACH	GSR →	+1.823	+0.446	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042180 vs AKR1A1 — LUNG_SCLC

Explore this scatter interactively →