DNA strand invasion

Across TCGA patient cohorts, RNA activity of the DNA strand invasion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, RRM2, and SMC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand invasion activity versus RFC4 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC4 →	+0.660	+0.155	<.001	<.001	3	10
LUAD	RRM2 →	+0.917	+0.113	<.001	<.001	3	10
LUAD	SMC2 →	+0.707	+0.119	<.001	<.001	3	10
LSCC	TIMELESS_S1173 →	+0.704	+0.079	<.001	<.001	3	10
LUAD	TOP2A →	+1.097	+0.112	<.001	<.001	3	10
GBM	UNG_S23 →	+1.096	+0.131	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042148 vs RFC4 — GBM

Explore this scatter interactively →