Meiotic DNA double-strand break formation

Across TCGA patient cohorts, RNA activity of the Meiotic DNA double-strand break formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF11_T926, TOP2A_S1247, and CDK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic DNA double-strand break formation activity versus KIF11_T926 in GBM (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF11_T926 →	+1.030	+0.125	<.001	.002	3	8
BRCA	TOP2A_S1247 →	+1.254	+0.150	<.001	<.001	3	8
LSCC	CDK1 →	+0.633	+0.120	<.001	<.001	3	7
GBM	DLGAP5 →	+0.842	+0.163	<.001	<.001	3	7
BRCA	RRP36_S73 →	+0.900	+0.141	<.001	<.001	3	7
GBM	TOP2A_S1377 →	+0.871	+0.115	.003	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042138 vs KIF11_T926 — GBM

Explore this scatter interactively →