Meiotic DNA double-strand break formation

Across TCGA pan-cancer cohorts, RNA activity of the Meiotic DNA double-strand break formation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Meiotic DNA double-strand break formation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

BRCA, LUSC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.870	0.944	<.001	49	view →
LUSC	OS	Median	All	0.486	0.335	.001	39	view →
LGG	DFS	Median	All	0.674	0.793	<.001	33	view →
SARC	DFS	Tertile	All	0.236	0.435	<.001	30	view →
CESC	OS	Tertile	IV	0.276	0.709	.002	26	view →
UVM	OS	Quartile	All	0.385	0.871	.011	25	view →
LUAD	DFS	Median	IV	0.817	0.511	.022	24	view →
THYM	OS	Median	All	1.000	0.923	.013	23	view →
PAAD	DFS	Median	III,IV	0.370	0.853	.010	15	view →
PCPG	DFS	Median	All	0.951	0.817	.007	14	view →
HNSC	OS	Quartile	III,IV	0.741	0.573	.016	14	view →
KIRC	OS	Quartile	All	0.741	0.589	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0042138–BRCA (OS)

Open the BRCA breakdown →