Regulation of meiotic nuclear division

Across TCGA patient cohorts, RNA activity of the Regulation of meiotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC3_S71, RRBP1_S615, and RRM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of meiotic nuclear division activity versus TACC3_S71 in LUAD (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TACC3_S71 →	+1.142	+0.087	<.001	<.001	3	5
LUAD	RRBP1_S615 →	+0.625	+0.058	<.001	.004	3	4
UCEC	RRM1 →	+0.389	+0.051	.001	.004	3	4
GBM	SMC4 →	+0.485	+0.057	.001	<.001	3	4
LUAD	TIMELESS_S1173 →	+0.399	+0.065	<.001	<.001	3	4
CCRCC	BMP1 →	+1.024	+0.040	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040020 vs TACC3_S71 — LUAD

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