Membrane fusion involved in viral entry into host cell

Across TCGA cell cohorts, RNA activity of the Membrane fusion involved in viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UXS1, STAT5A, and AHNAK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UXS1 grouped by Membrane fusion involved in viral entry into host cell-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UXS1 →	-0.504	-0.657	.002	.007	3	5
UPPER_AERODIGESTIVE_TRACT	STAT5A →	+1.684	+1.562	.002	<.001	3	4
URINARY_TRACT	AHNAK →	-1.111	-1.417	<.001	.001	3	4
OESOPHAGUS	UCP2 →	-3.090	-1.090	<.001	<.001	3	4
STOMACH	MXRA7 →	+3.456	+1.209	.002	.003	3	4
LIVER	PPM1J →	-0.885	-1.152	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UXS1 by Membrane fusion involved in viral entry into host cell activity — LUNG_SCLC

Explore this box plot interactively →