Membrane fusion involved in viral entry into host cell

Across TCGA pan-cancer cohorts, RNA activity of the Membrane fusion involved in viral entry into host cell pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Membrane fusion involved in viral entry into host cell pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UVM, show the opposite pattern, with higher activity associated with better survival.

BLCA, COAD, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.329	0.641	<.001	88	view →
COAD	DFS	Tertile	All	0.578	0.770	<.001	62	view →
LUSC	OS	Median	All	0.309	0.493	<.001	49	view →
LUAD	OS	Tertile	All	0.545	0.282	.001	37	view →
ESCA	DFS	Median	All	0.336	1.000	<.001	30	view →
UCEC	OS	Quartile	All	0.616	0.819	.016	24	view →
UVM	DFS	Tertile	II,III,IV	0.629	0.334	.014	22	view →
KIRP	DFS	Median	III,IV	0.446	0.742	.009	19	view →
GBM	DFS	Quartile	All	0.183	0.331	.004	18	view →
MESO	OS	Tertile	All	0.309	0.732	.019	12	view →
BRCA	DFS	Quartile	All	0.858	0.905	.027	12	view →
ACC	OS	Median	II,III,IV	0.851	0.672	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0039663–BLCA (OS)

Open the BLCA breakdown →