Negative regulation of RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX58, IFI35, and NLRX1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RIG-I signaling pathway activity versus DHX58 in UCS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	DHX58 →	+1.147	+0.077	<.001	<.001	3	29
UCS	IFI35 →	+1.472	+0.080	<.001	<.001	3	27
UCS	NLRX1 →	+1.268	+0.117	<.001	<.001	3	25
UCS	UBA7 →	+1.397	+0.090	<.001	<.001	3	25
UCS	XAF1 →	+0.990	+0.063	.004	.002	1	26
UCS	PARP10 →	+1.549	+0.096	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039536 vs DHX58 — UCS

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