Negative regulation of RIG-I signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of RIG-I signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Negative regulation of RIG-I signaling pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and KICH, show the opposite pattern, with higher activity associated with better survival.

KIRC, LIHC, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.522	0.681	.001	65	view →
LIHC	OS	Tertile	II,III,IV	0.687	0.327	.003	49	view →
LAML	DFS	Median	All	0.214	0.560	.002	36	view →
ACC	DFS	Median	All	0.176	0.774	<.001	36	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.593	.005	29	view →
ESCA	DFS	Tertile	III,IV	0.528	0.230	.004	26	view →
COAD	DFS	Median	II,III,IV	0.570	0.774	.003	26	view →
UCS	DFS	Tertile	IV	0.956	0.380	.024	24	view →
KIRP	DFS	Median	All	0.967	0.606	.002	20	view →
SCLC	DFS	Median	III,IV	0.506	0.244	.020	20	view →
LGG	DFS	Tertile	All	0.805	0.876	.013	12	view →
SARC	DFS	Tertile	All	0.637	0.264	<.001	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0039536–KIRC (DFS)

Open the KIRC breakdown →