Negative regulation of RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of RIG-I signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH18A1, ZNF622_S143, and AHNAK_S5332, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RIG-I signaling pathway activity versus ALDH18A1 in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ALDH18A1 →	-0.275	-0.035	.006	.006	3	5
GBM	ZNF622_S143 →	-0.217	-0.054	.009	<.001	3	5
BRCA	AHNAK_S5332 →	+0.579	+0.037	<.001	<.001	3	5
COAD	ZC3H15 →	-0.226	-0.029	<.001	.003	3	4
CCRCC	ALG3 →	-0.896	-0.052	.001	<.001	3	4
COAD	HUWE1 →	-0.173	-0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039536 vs ALDH18A1 — COAD

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