Negative regulation of RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYF2, WDR35, and DENND4C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of RIG-I signaling pathway activity versus SYF2 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYF2 →	-0.243	-0.120	.005	.004	3	4
UCEC	WDR35 →	-0.756	-0.149	.001	.002	3	4
BRCA	DENND4C →	-0.930	-0.225	<.001	<.001	3	4
BRCA	NEDD1 →	-0.658	-0.292	<.001	<.001	3	4
LSCC	MEIS3P2 →	-0.671	-0.144	.001	<.001	3	4
BRCA	MKRN2 →	-0.336	-0.181	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039536 vs SYF2 — LSCC

Explore this scatter interactively →